The National Research Council has released the report: A Framework to Guide Selection of Chemical Alternatives (2014 ) intended to help government and industry select from current tools on how to find safer alternatives for chemicals of concern in products. It offers a stepwise process, with several of them optional, for the kinds of analyses and screening tools that can be used to meet substitution needs.
Framing and scoping the effort are called out as a key, as is the need for comparative exposure assessment. It's nice to see the NRC goes beyond simply focusing on hazard and looks for relative risk as the driver for substitution. The report also describes the process as tiered and iterative, with plenty of research still needed to understand how best to use 21st century fast throughput and computer models based on physical/chemical properties. The report also supports transparency and acknowledgement of uncertainty.